2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N9777
    Procyanidin B-5 3,3'-di-O-gallate 106533-60-2 98%
    Procyanidin B-5 3,3'-di-O-gallate is a potent inhibitor of squalene epoxidase with an IC50 of 0.55 μM. Procyanidin B-5 3,3'-di-O-gallate reduces cholesterol by inhibiting squalene epoxidase activity.
    Procyanidin B-5 3,3'-di-O-gallate
  • HY-NP170
    Holo Transferrin (Bovine) 98%
    Holo Transferrin (Bovine) (HTF (Bovine)) is a glycoprotein that acts as a growth factor. Binding of Holo Transferrin (Bovine) to its receptor is necessary for cells to initiate and maintain their DNA synthesis.
    Holo Transferrin (Bovine)
  • HY-P1994
    JMV 167 120775-49-7 98%
    JMV 167 is antagonist of peripheral cholecystokinin receptor (CKK), with an IC50 of 500 nM.
    JMV 167
  • HY-P2357
    MI-1544 87565-51-3 98%
    MI-1544 is a powerful GnRH antagonist. MI-1544 induces inhibitory effects on the pituitary LH release and on gonads. MI-1544 can be used for the research of antifertility effect.
    MI-1544
  • HY-P2858
    β-Mannosidase 9025-43-8 98%
    β-Mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single β(1-4)-linked mannose at the nonreducing end of N-glycosylated proteins, and plays an important role in the polysaccharide degradation pathway.
    β-Mannosidase
  • HY-P5245
    Ac-KLKKTETQ-NH2 934812-87-0 98%
    Ac-KLKKTETQ-NH2, a peptide, has the potential for cosmetics research.
    Ac-KLKKTETQ-NH2
  • HY-P5265
    Tetrapeptide 31008-44-3 98%
    Tetrapeptide, an analogue of α-MSH, induces melanin synthesis. Tetrapeptide diminishes DNA damage by reducing the production of reactive oxidative species and enhancing repair of DNA photoproducts.
    Tetrapeptide
  • HY-Z3637
    (–)-Sitagliptin carbamoyl glucuronide 940002-59-5 98%
    (–)-Sitagliptin carbamoyl glucuronide is a minor metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor Sitagliptin (HY-13749).
    (–)-Sitagliptin carbamoyl glucuronide
  • HY-Z7659
    Lansoprazole sulfone N-Oxide 953787-54-7 98%
    Lansoprazole sulfone N-Oxide (Comound 3) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole sulfone N-Oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome.
    Lansoprazole sulfone N-Oxide
  • HY-Z7660
    Lansoprazole N-oxide 213476-12-1 98%
    Lansoprazole N-oxide (Comound 2) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole N-oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome.
    Lansoprazole N-oxide
  • HY-Z8472
    Dihydromevinolin 77517-29-4 98%
    Dihydromevinolin is a potent hypocholesterolemic metabolite produced by Aspergillus terreus. Dihydromevinolin is a HMG-CoA reductase inhibitor.
    Dihydromevinolin
  • HY-10003R
    Alfacalcidol (Standard) 41294-56-8
    Alfacalcidol (Standard) is the analytical standard of Alfacalcidol. This product is intended for research and analytical applications. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis.
    Alfacalcidol (Standard)
  • HY-100045
    p-Nitrophenyl phosphorylcholine 21064-69-7 98%
    p-Nitrophenyl phosphorylcholine (4-Nitrophenylphosphorylcholine) is a chromogenic substrate that is used to measure phospholipase C (PLC) activity. Hydrolysis of p-nitrophenylphosphorylcholine by PLC results in the liberation of p-nitrophenol, which can be measured at 405 nm at pH 7.2-7.5.
    p-Nitrophenyl phosphorylcholine
  • HY-100288
    RP 73163 Racemate 136609-53-5 98%
    RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity.
    RP 73163 Racemate
  • HY-100308
    SB-568849 395679-53-5 98%
    SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7.
    SB-568849
  • HY-100334
    Pirinixil 65089-17-0 98%
    Pirinixil is a hypolipidemic agent of low toxicity.
    Pirinixil
  • HY-101683
    Deriglidole 122830-14-2 98%
    Deriglidole is a peripheral adrenoceptor antagonist with a high affinity for α2-adrenoceptors.
    Deriglidole
  • HY-10195R
    Ruboxistaurin (Standard) 169939-94-0 98%
    Ruboxistaurin (Standard) is the analytical standard of Ruboxistaurin. This product is intended for research and analytical applications. Ruboxistaurin (LY333531) is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin exhibits ATP dependent competitive inhibition of PKC beta I with an IC50 of 4.7 nM. Ruboxistaurin inhibits PKC beta II with an IC50 of 5.9 nM.
    Ruboxistaurin (Standard)
  • HY-10284R
    Linagliptin (Standard) 668270-12-0
    Linagliptin (Standard) is the analytical standard of Linagliptin. This product is intended for research and analytical applications. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
    Linagliptin (Standard)
  • HY-10285R
    Saxagliptin (Standard) 361442-04-8
    Saxagliptin (Standard) is the analytical standard of Saxagliptin. This product is intended for research and analytical applications. Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research.
    Saxagliptin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity